Niacin Therapy, HDL Cholesterol, and Cardiovascular Disease: Is the HDL Hypothesis Defunct?
نویسندگان
چکیده
منابع مشابه
Non-HDL Cholesterol and Evaluation of Cardiovascular Disease Risk
Cardiovascular disease (CVD), such as coronary heart disease (CHD), is the most frequent cause of death worldwide, especially in developed countries. The latest recommendations of European and American Cardiological Associations emphasize the role of non-HDL cholesterol (non-HDL-C) in evaluating the risk of CVD. Although this parameter has a lot of advantages, it is rarely used by general pract...
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Dyslipidaemia is one of the major risk factors for the development of cardiovascular disease, which remains the leading cause of death in the world. Despite major advances in the treatment of dyslipidaemia, residual cardiovascular risk remains high in a significant number of patients, a fact that has prompted intensive investigation of medications raising HDL-cholesterol (HDL-C). Indeed, robust...
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It is a great irony that the earliest discovered lipoprotein is also the least well understood. In 1929, Michel Machebouef at the Pasteur Institute in Paris, using salt precipitation techniques, isolated a lipoprotein particle from horse serum composed predominantly of an a-globulin (59%), which we now know to be high-density lipoprotein (HDL) (1). Epidemiological studies in the 1970s, includin...
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One strategy for treating coronary artery disease (CAD) patients with low HDL cholesterol (HDL-C) is to maximally increase the HDL-C to LDL-C ratio by combining lifestyle changes with niacin (N) plus a statin. Because HDL can prevent LDL oxidation, the low-HDL state also may benefit clinically from supplemental antioxidants. Lipoprotein changes over 12 months were studied in 153 CAD subjects wi...
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Initial observational studies have identified high-density lipoprotein cholesterol (HDL-C) as an independent predictor of cardiovascular (CV) risk, even in patients on optimal statin therapy. However, the notion that higher HDL-C is better, has been seriously challenged by the results from several recent clinical and genetic trials. Data from the CANHEART study serve to clarify the relation bet...
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ژورنال
عنوان ژورنال: Current Atherosclerosis Reports
سال: 2015
ISSN: 1523-3804,1534-6242
DOI: 10.1007/s11883-015-0521-x